Interesting stuff I am hearing in trying to treat this.
1. As mentioned, they are using the plasma from recovered people to treat other patients. The reason is due to antibody formation in the plasma. Initially China was just reported medical staff doing it (as there is some degree of reluctance to donate blood in china), but now they are reporting average people donating blood as well.
2. Xinhua is reporting using chloroquine to try.
http://www.xinhuanet.com/english/2020-0 ... 792545.htm
Its interesting because chloroquine is an old antimalaria drug, but then this caught my eye with the suggested mechanisms.
Previous in vitro experiments showed that it can block virus infections by changing the acidity and basicity value inside the cell and interfering receptors of SARS coronavirus.
It also shows immune-modulating activity, which may enhance its antiviral effect in vivo and is widely distributed in the whole body, including the lungs, after oral administration.
Basically they are saying it alters pH value in cells which can interfere with how the virus reproduces. The article doesn't tell us do we lower it down (ie more acidic) or high ie more alkaline.
The other tidbit is interesting, about immune modulation. Because similar drugs like hydroxychloroquine is actually used to treat some autoimmune diseases like Lupus, so there may be something there.
3. Trying antiflu meds (or more specifically a Russian made one Umifenovir/Arbidol.
One study being done at the Guangzhou Eighth People's Hospital in China is testing Kaletra against Arbidol, an antiviral drug approved in China and Russia to treat the flu. Two groups of patients will take the medications along with standard care. A third group in the study will receive only standard care, typically supportive therapy with oxygen and IV fluids that are meant to support the body so the immune system can fight off a virus on its own.
Now umifenovir is not one we use in Australia. We tend to use oseltamavir or tamiflu, and even then, in someone who is not that sick, its only useful if given within the first 48 hours and that just speeds up recovery time. According to the wiki article on umifenovir, it supposedly has similar effects to tamiflu. Even if all it does is speeds up recovery rates, it can still be useful as they are still building new temporary hospitals to help in Hubei province.
4. Anti ebola drugs are being tested based on what we now in vitro they do coronaviruses
(same link as above)
An Ebola Drug Gets a Second Look
One repurposed drug generating a lot of buzz is an experimental infusion called remdesivir. It was originally tested against Ebola. While it didn't work for that infection, it has been shown to shut down the new coronavirus, at least in test tubes.
It's been given to a small number of COVID-19 patients already, including one in Washington state.
In order to have better evidence of how well it may work in people, two studies in Beijing are comparing remdesivir to a dummy pill to see if the drug can help patients with both mild and severe symptoms recover from their illnesses.
There is more which is promising. Remdesivir is a nucleotide analogue. Some antiviral drugs against hepatitis works on this premise where we trick the virus into subtituting one its building blocks. Some drugs are nucleotide analogues and some are nucleoside analogues, the difference is in the structure to make one a nucleotide or another a nucleoside.
5 another antiviral tested is Favipiravir
https://www.plenglish.com/index.php?o=r ... t-covid-19
Never heard of this one myself, wiki says its manufactured by a japanese company and thought to work by inhibiting RNA replication in viruses.
So lets see what happens, but the world is reacting quite fast to testing new treatments.
Never apologise for being a geek, because they won't apologise to you for being an arsehole. John Barrowman - 22 June 2014 Perth Supernova.
Countries I have been to - 14.
Australia, Canada, China, Colombia, Denmark, Ecuador, Finland, Germany, Malaysia, Netherlands, Norway, Singapore, Sweden, USA.
Always on the lookout for more nice places to visit.