If you can telekinetically lift a speedster off the ground, they can't do anything to you. Similarly some sort of magnetic field should do the trick.
The key is to prevent them from building up momentum.
There was an episode of X-Men Evolution where Jean Grey tries that on Quicksilver, it does not end well for her.
Jim Raynor wrote:
I read about that infamous instance of Wally West sitting in a theater, feeling a bullet he never saw on the skin of his neck, and moving out of the way after that. Which is total wank which I can't see being justified on any narrative grounds. If that's how the Flash's powers operate, then no one should EVER get the jump on him or even touch him during battle. Yet his most enduring enemies include "guy with boomerangs" and "guy with flamethrower."
Don't forget about the part where he then casually walks around the theater (at superspeed of course) and plucks the various bullets hanging about in mid-air so he can dispose of them before anyone gets hurt.
And the Flash is just ridiculous. He's actually faster than light, can vibrate through solid matter, time-travel and dimension hop casually, and is has an 'aura' (ver scientific) that makes him immune to the friction heat he generates with his running, and by extension any other sort of heat weapon.
Which, yes, makes Heat Wave even more superfluous, but I thought he was a C-lister and not a "most enduring enemy" like Cold, Mirror Master, Trickster, et al.
I've theorised before that the 'Speed Force' is just a bullshit explanation for how the Flash really gets aorund, activating his time travel powers on a subconcious level whenever he starts running quick enough.
The Speed Force acts as some giant energy sink/store. All the negative effects of traveling at Mach speeds and higher, just dump all that energy into the Speed Force. Need to travel through time? Just hop a ride in the Speed Force (dimensional travel is performed similarly). Also, thanks to a far greater deal of control over the Speed Force than any of his predecessors Wally can actually add or remove speed
from any object he wants. I mean seriously, the man has Gambit as the New Sun
level control over energy in his pocket and just fools around practically 24/7. Oh yeah, and the Speed Force, it's made out of Time.
Anyway, as has been said, you'd need to create a reliable trap to engage any speedster, even in real life. Just having one jump you in the middle of a crime would likely end in you going to prison 95% of the time.
If we are sticking with Comicbook speedsters though, you could have some Mad Scientist villian who has developed a weapon that cuts-off the Hero's connection to whatever force is providing their speed. That actually happened to Wally a couple times (well it wasn't by a villian, it was the result of dimensional travel) and limited him to only breaking the sound barrier.