TDW was an extremely well-written, well-executed episode that did what may be irreparable harm to the franchise
Frankly, the Silence and the army that created River would be entirely justified in their thinking and would be wiped out in seconds.
I've got to be honest, I'm completely baffled by their motivations. They claim that they're trying to kill him because he is to dangerous and a threat to the universe? Fair enough. Then eyepatch lady tells him to his face she isn't afraid of his threats because he is a good man. So your position is to find a powerful individual, who is dangerous, yes, but fundamentally has good intentions for pretty much everyone, and try to kill him by kidnapping his friends and their children and brainwashing them into assassins. Does it not occur to them that this sort of thing is likely to drive him to being the galaxy devouring horror they're so afraid of?
I was struck with a terrible feeling that this is all going to come back into play later with the Doctor's "death" on the beach.
Given that he flat out stated that knowing your future makes it possible to change it if you're bloody minded and clever enough, I'd say so. This still bugs me though, why was River so insistent they not tell him they saw him die. He invited them and his past self to his own death, so he clearly knew how and when he was going to die already, which means it can't matter that much if they tell him, and he may actually be able to take steps to, you know, not get shot and die?