Engineering T cells to treat pancreatic cancer

[SolarpunkFan]

https://www.sciencedaily.com/releases/2 ... 204553.htm

Dr. Sunil Hingorani, a member of the Clinical Research and Public Health Sciences divisions at Fred Hutchinson Cancer Research Center, will present recent groundbreaking developments in treating pancreas cancer with engineered T-cells at the American Association for Cancer Research Annual Meeting 2016 in New Orleans on April 16.

Hingorani, a pancreatic cancer specialist, teamed up with Fred Hutch immunotherapy experts Drs. Phil Greenberg and Ingunn Stromnes in successful efforts to breach the cancer's physical and immunological walls using immunotherapy, a type of treatment that harnesses or refines the body's own immune system with T-cells engineered to recognize and destroy cancer cells.

Specifically, Hingorani's team created T cells with a high affinity to a "relatively" tumor-specific antigen. Why relatively? Notoriously difficult pancreatic tumor cells don't produce many unique proteins that allow for completely tumor-specific T cells. Instead, the team had to look for proteins that are expressed in unusually large amounts in the tumor cells and minimally expressed elsewhere. The T cells then were engineered to attack those.

Considering that pancreatic cancer is particularly nasty, this is good news.